组织因子途径抑制物2在肿瘤发生转移和侵袭中的作用

Tissue factor pathway inhibitor-2 in tumor migration and invasion

细胞外基质（extracellular matrix，ECM）降解是肿瘤发生浸润转移过程中的关键一步，肿瘤细胞分泌的多种丝氨酸蛋白酶包括基质金属蛋白酶（matrix metallopoteinases，MMPs）参与细胞外ECM降解。组织因子途径抑制物2（tissue factor pathway inhibitor-2，TFPI-2）是一种具有32000丝氨酸蛋白酶抑制物，可抑制包括纤溶酶、胰蛋白酶、MMPs在内的多种蛋白酶。越来越多的研究表明，TFPI-2通过降解MMPs等抑制肿瘤转移、降低肿瘤的侵袭转移能力。TFPI-2在抑制肿瘤细胞迁徙及浸润转移过程中发挥重要作用，可作为一种潜在的基因治疗靶点。

The proteolytic degradation of extracellular matrix （ ECM ） is the critical step for tumor cell invasion, and a variety of serine proteases, as well as plasmin, trypsin, matrix metalloproteinases （ MMPs ） are shown to play a major role in matrix degradation, so decreasing the proteases and maintaining the integrity of extracellular matrix may inhibit the invasion of tumor cell. Tissue factor pathway inhibitor-2 （TFPI-2 ） is a 32000 serine protease inhibitor with broad inhibittory spectra that inhibits plasmin, trypsin, MMPs and so on. It plays a major role in tumor cell invasion and metastasis and angiogenesis. Researches show TFPI-2 inhibit the migration and invasion of tumor through degradating MMPs, playing a major role in the migration and invasion of tumor, so it may be a potential target site for gene therapy.