期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

血浆蛋白质组学在乳腺癌早期诊断研究中的进展

Plasma proteome in early diagnosis breast cancer
原文传递
导出
摘要 血浆作为临床诊断及预后评估中的重要研究样品，其组成中蛋白及多肽类成分的分析成为寻找疾病标志物的重要途径。血浆蛋白质组学研究近年来成为国际蛋白质组学研究的热点。现就血浆蛋白质组学与乳腺癌早期诊断的肿瘤标志物的研究进展进行综述。 Plasma has been clinically used for diagnosis and prognosis evaluation. Analysis of proteins and peptides in plasma provides a powerful approach for identification of disease-specific biomarkers. Research on plasma proteome has become a hot spot in the recent. In this review, we describe the advances of plasma proteome in candidate biomarker identification for early diagnosis of breast cancer.
作者 陈庆永 陈道达
机构地区 华中科技大学同济医学院附属协和医院普外科
出处 《国际外科学杂志》 2007年第1期35-38,共4页 International Journal of Surgery
关键词 血浆 蛋白质组学 乳腺肿瘤 早期诊断 plasma proteome breast neoplasm diagnosis
分类号 R737 [医药卫生—肿瘤]
  • 相关文献

参考文献17

  • 1Anderson NL, Anderson NG. The human plasma proteome: history, character, and diagnostic prospects [ J ]. Mol Cell Proteomics, 2002,1 ( 11 ) :845-867.
  • 2Hortin GL. The MALDI-TOF mass spectrometric view of the plasma proteome and peptidome [ J ]. Clin Chem, 2006, 52 (7) :1223-1237.
  • 3Wulfkuhle JD, McLean KC, Paweletz CP, et al,New approaches to proteomic analysis of breast cancer [ J ]. Proteomics,2001,1 (10) :1205-1215.
  • 4Pieper R, Su Q, Gatlin CL, et al. Multi-component immunoaffinity subtraction chromatography: an innovative step towards a comprehensive survey of the human plasma proteome [ J ]. Proteomics, 2003, 3 (4):422-432.
  • 5Steel LF, Trotter MG, Nakajima PB, et al. Efficient and specific removal of albumin from human serum samples [ J ]. Mol Cell Proteomics, 2003,2 (4) : 262-270.
  • 6Pieper R, Gatlin CL, Makusky AJ, et al, The human serum proteome : display of nearly 3700 chromatographically separated protein spots on two-dimensional electrophoresis gels and identification of 325 distinct proteins [ J 1. Proteomics, 2003, 3 (7) :1345-1364.
  • 7Petricoin EF, Ardekani AM, Hitt BA, et al. Use of proteomic patterns in serum to identify ovarian cancer [ J ]. Lancet, 2002,359(9306) : 572-577.
  • 8Adkins JN, Varnum SM, Auberry KJ, et al. Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry [ J ]. Mol Cell Proteomics, 2002,1(12):947-955.
  • 9Poon TC, Yip TT, Chan AT, et al. Comprehensive proteomic profiling identifies serum proteomic signatures for detection of hepatocellular carcinoma and its subtypes[ J]. Clin Chem, 2003,49(5) : 752-760.
  • 10Petricoin EF 3rd, Ornstein DK, Paweletz CP, et al. Serum proteomic patterns for detection of prostate cancer[ J]. J Natl Cancer Inst, 2002, 94(20) : 1576-1578.
国际外科学杂志
2007年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部