异十三基二乙胺体内抗肿瘤作用

Antitumor activity of allotri-tridecyl diethylamine in vivo

目的探讨异十三基二乙胺(D-108)的体内抗肿瘤作用。方法应用小鼠移植性实体瘤U14及腹水瘤HAC,观察可耐受剂量下药物对肿瘤生长的抑制作用。观察不同给药途径D-108对小鼠的急性毒性。结果D-108腹腔注射及灌胃均能有效抑制U14在小鼠体内的生长,腹腔注射12 mg/(kg.d)及灌胃100 mg/(kg.d)瘤质量抑制率分别为38.54%及45.27%;皮下注射及灌胃也均能延长HAC荷瘤小鼠的生存时间,皮下注射20 mg/(kg.d)及灌胃100 mg/(kg.d)生命延长率分别是36.30%及39.43%。Bliss法计算,D-108腹腔注射、皮下注射及灌胃的LD50分别是43.7,230.9,415.1 mg/kg。结论D-108不同途径给药对荷瘤小鼠均有较强的体内抗肿瘤活性。

Objective To investigate antitumor effect of allotri-tridecyl diethylamine （D-108） in vivo. Methods D-108 was administrated to mice with transplanted solid tumors U14 and ascitic cancer HAC. Tumor weight of U14 and survival time of the mice implanted HAC were observed. The acute toxicity on mice was observed via different administration routes of D-108. Results D- 108 intraperitoneal injection（ip） and intragastric adrninistration（ig） could effectively inhibit in vivo growth of implanted solid tumor U14 in mice. The inhibition rates of tumor weight of D-108 12 mg/（kg·d） （ip） and 100 mg/（kg·d） （ig） were 38.54% and 45.2796, respectively. D-108 subcutaneous injection（sc） and ig could prolong the survival time of mice implanted with ascitic cancer HAC. The rates of life extension of the mice with D-108 20 mg/（kg·d）（sc） and 100 mg/（kg·d）（ig） were 36.30 % and 39.43 %, respectively. LDs0ofD-108inmicewere43.7mg/kg（ip）, 230.9mg/kg（sc） and415.1 mg/kg（ig） by Bliss method. Conclusion D-108 has obvious antitumor activity in vivo in different administration routes.