新生儿轮状病毒肠炎23例临床与流行病学分析

Clinical and epidemiological analysis on 23 cases of neonatal rotavirus enteritis

目的回顾性分析某院新生儿病区轮状病毒肠炎患儿的临床特征与流行规律,探讨预防与控制对策。方法查阅新生儿病区2006年初的23例轮状病毒肠炎患儿病历,对其临床资料与实验室结果进行分析。结果轮状病毒肠炎新生儿以腹泻入院者5例,支气管肺炎入院者17例,高胆红素血症1例。大便轮状病毒抗原检测均为阳性;轮状病毒核酸PAGE检测10例,其中5例阳性,证实为A组轮状病毒感染,分3个基因型。粪-口传播是本次感染的主要传播途径。结论在轮状病毒肠炎好发季节,除应对肠炎患儿进行隔离和大便轮状病毒检测外,对呼吸系统感染并腹泻患儿也要采取上述措施,并应加强环境消毒等,杜绝轮状病毒肠炎在病区内流行。

Objective To analyse retrospectively the clinical and epidemiological features of neonatal rotavirus en teritis in a hospital , and to evaluate the preventive and control measures. Methods Medical records of 23 neonates with rotavirus enteritis in a neonatal unit in 2006 were reviewed , clinical and laboratory data were analysed. Results Admission diagnosis of neonates with rotavirus infection were 5 cases of diarrhea, 17 cases of bronehopneumonia and 1 case of hyperbilirubinemia. Stool rotavirus antigen detection were all positive; 10 neonates were performed rotavirus nucleic acid PAGE detection, 5 of which were positive , which proved to be group A rotavirus infection . The main transmission route of the infection was fecal-oral route. Conclusion In the peak season of developing rotavirus enteritis , in addition to the isolation of the infected neonates and detection of stool rotavirus, neonates with respiratory infection combined with diarrhea should also take the above measures , environmental disinfection should be strengthened to prevent the transmission of rotavirus infection among community.