大环内酯类药物序贯疗法治疗肺炎支原体肺炎的体会

Evaluation of macrolides sequential therapy for the treatment of Mycoplasma pneumonia pneumonia

目的探讨序贯疗法在肺炎支原体肺炎（MPP）治疗中的应用疗效。方法将131例MPP患儿随机分为治疗组66例，对照组65例。治疗组治疗方法：5％葡萄糖加红霉素静脉滴注，每日1次，同时口服罗红霉素，每晚1次，7d热退后，停静脉滴注，改阿奇霉素13服2个疗程；对照组：5％葡萄糖加红霉素及维生素R静脉滴注，每日1次，共14～21d；比较两组临床观察结果。结果治疗组治疗有效率为93．94％，对照组为67．69％，两者比较，差异有显著性（P＜0．01）。治疗组热退天数为（5．0±1．2）d，胸片好转天数为（7．0±1．1）d，发生并发症7例，药物不良反应17例；对照组热退天数为（9．0±1．3）d，胸片好转天数为（10．0±1．4）d，发生并发症16例，药物不良反应52例；两组上述各项比较，差异均有显著性（P＜0.01或P＜0．05）。结论采用序贯疗法治疗MPP疗效好，疗程短，并发症少，依从性好。

Objective To evaluate the curative effect of maerolides sequential therapy for the treatment of Mycoplasma pneumonia pneumonia （MPP）. Methods One hundred and thirty-one cases of MPP were divided randomly into treatment group （66 cases） and control group （65 cases）. The curative method in treatment group were as follows ：5% glucose and erythromycin for intravenous drip once a day , oral administration of roxithromycin once per night simultaneously, after the abatement of fever 7 days later, intravenous drip was stopped, azithromyein was administered orally for two treatment courses; the curative methods in control group were as follows ： 5% glucose and erythromycin and vitamin B5 for intravenous drip once a day, the treatment course was 14～21 days , curative effect of two groups were compared. Results The curative effect in treatment group and control group was 93.94G and 67. 69% respectively , there was significant difference between two groups （P〈0.01） , in treatment group , the period of abatement of fever were （5.0±1.2） days, the period of improvement of chest X-ray were （7.0 ± 1.1） days, 7 cases had complications , 17 cases had side effect of drug ; in control group , the period of abatement of fevet were （9. 0±1.3） days, the period of improvement of chest X-ray were （10. 0±1.4） days, 16 cases had complications , 52 cases had side effect of drug;there were significant difference between the respective results （P〈0.01or P〈0. 05）. Conclusion Sequential therapy has good effect for treating MPP, the treatment course is short and had little complication.