ER、PR及β_2－MG检测在膀胱癌诊断、预后估计中的价值

The Determination of ER, PR and β_2-microglobulin Expression of Bladder Cancer Tissue In The Diagnosis And Prognosis Estimation of Bladder Tumor

本文首次应用免疫组化ＰＡＰ法检测膀胱癌组织中的ＥＲ、ＰＲ（２８例）及β２－ＭＧ（３５例）的表达状况。结果表明：ＥＲ（＋）者１０例（３５．７％）、ＰＲ（＋）者８例（２８．６％），β２－ＭＧ（＋）者１５例（４２．９％）。肿瘤的组织分级和临床分期与ＥＲ、ＰＲ表达里正相关，与β２－ＭＧ的表达呈负相关，随访五年其复发率和死亡率ＥＲ（＋）者、ＰＲ（＋）者高于阴性者，β２－ＭＧ（＋）者低于阴性者。证明ＥＲ、ＰＲ存在于膀胱癌组织中，对诊断及预后的估计有一定的价值，并与β２－ＭＧ是二组相邀指标。认为对膀胱癌ＥＲ、ＰＲ阳性患者可试行辅助性内分泌治疗。

bladder cancer patients were evaluated for β2-microglobulin expression by means of PAP method and 28 of them for also ER and PR. Result showed that ERwas positive in 10 cases(35.7%),PR positive in 8 cases (28. 6%)and β2-microglobulin positive in 15 cases (42.9%).There was a positive correlation between cancer histologic grading, clinical staging and ER, PR content, while a negative correlation existed between the former and β2-microglobulin. In 5 year follow-up study, the recurrence and mortality rate of ER(+ ),and PR (+ ) patient were higher than that of ER(-), PR(-) patient, while that of β2-microglobulin(+) patient were lower than in β2-microglobulin(-) patient. This suggests that ER and PR are present in bladder cancer tissue, they might play a role in evaluating the diagnosis and prognosis of bladder tumor.In addition,ER and PR two groups of marker opposite to each other. on the basisof and β2-microglobulin are two groups of marker opposite to each other. On the basis of this study, it stands to reason that the adjuvant hormonal therapy is tried in ER, PR positive bladder cancer patient.