恶性肿瘤患者血清中结肠癌抗原的测定

Detection or Colon Carcinoma-associated Antigen With Antibody in Sera of Patients

本文采用肠癌相关抗原（ＣＣＡ）双抗体夹心免疫酶标法，检测了７４例恶性肿瘤患者和７８例非恶性肿瘤患者的血清标本发现７４例各类恶性肿瘤总的血清ＣＣＡ灵敏度５１．３５％（３８／７４），其中胃肠道癌为７２．９７％（２７／３７），原发性肺癌为３２．１４％（９／２８）。７８例非肿瘤患者的血清ＣＣＡ特异性９１．９３％（７１／７８）。结果表明ＩＧ（１０）单抗所识别的ＣＣＡ尽管不能说是胃肠道癌专一性的肿瘤标志物，但就胃肠道癌患者血清中的阳性检出率面言，是目前较好的肿瘤标志物之一。与ＣＥＡ同用于恶性肿瘤患者的检测，灵敏度可提高。

Colon carcinoma-associated antigen(CCA)was detected with sandwich ELESA method in sera of 74 cases of patients with malignant tumors and 78 cases of patients with other diseases.Total sensitivity was 51.35% in all of the maligancy in which, gastrointestinal carcinoma was of 72. 97%, primay long carcinoma 32.14%.Total specificity was 91.03% in all of the benign diseases.These results showed that although the CCA that IG10 monoclonal know is not specific tumor marker of gastrointestinal carcinoma,the CCA is better tumor marker from the sera positive rate of gastrointestinal carcinoma. The sensitivity could be raised when CCA and CEA are detected in the patients sera in same time.