吗丁啉预防化疗所致呕吐的临床研究

The Effecacy of Domperidone as a Preventing Emetic Agnet in Chemotherapy-Induced Emeses

吗丁啉为多巴胺－Ｄ２受体阻滞剂，极少中枢神经系统副作用。我们以口服负荷量加舌下含化维持量吗丁啉作为化疗呕吐的预防剂，对含中剂量ＤＤＰ（４０ｍｇ×３天）化疗方案呕吐的完全控制率为７４．３％，对不含ＤＤＰ化疗方案的呕吐完全控制率为８１．８％，同期枢复宁对合中剂量ＤＤＰ（４０ｍｇ×３天）化疗方案的呕吐完全控制率为７４．０％。本研究表明，吗丁啉预防化疗呕吐有效，无明显毒副作用，价廉，用法简便，值得进一步研究。

Domperidone is a dopamin receptor blocker which is few adverses. Domperidone is admited by oral loaded dose and following by sublingual sustaining dose to prevert chemotherapy-induced emeses. The complete control rate of emese is 74.3% in containing MD-cisplatin regimens, 81.8% in containing middle-induced emeses agents and ondansetron is 74.0% in containgin MD-cisplatin regimens.Domperidone is not significant adverses and its expanse is much low.