肿瘤坏死因子-α与2型糖尿病及其大血管并发症的关系

Tumor necrosis factor-α and type 2 diabetes mellitus

目的探讨肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)与2型糖尿病及其大血管并发症的关系。方法国内外许多学者通过放免法或ELISA法分别测定健康人群、2型糖尿病及合并大血管病变患者血浆TNF-α水平,并对结果进行严格的统计处理和分析。结果2型糖尿病患者TNF-α水平增加,合并大血管病变患者升高更明显。结论TNF-α作为一种炎症反应相关的细胞因子,通过不同途径参与胰岛素抵抗和大血管并发症的发生,可为糖尿病的预防和治疗提供新的研究方向。

Objective To study the relativity between TNF-α and type 2 diabetic patients with macrovascular complications. Methods Many scolors in and abrord have investigated the TNF-α changes in type 2 diabetic patients with and without macrovascular .The plasma TNF-α levels was assayed through radioimmunoassay or ELISA and the results were coneluded through stricitly statistical analysis.Results The level of TN-αin type 2 diabetic patients with macrovascular complications was significantly higher than those without complications and even more in the normal controls ; the level of TNF-α in type 2 diabetic patients was higher than that in the normal controls. Conclusion Tumor necrosis factor-α is a cytokine closely associated with insulin resistance and macrovascular complications in type 2 diabetes.This will provide a new research field in the development of new preventive and therapeutic drugs for diabetes.