3种抗癫痫药物的血药浓度监测结果分析

Analysis of Monitoring Results in Serum Concentrations of Three Antiepileptics

目的了解3种常用抗癫痫药物血药浓度与临床疗效及药物相互作用的关系,促进临床合理用药。方法采用荧光偏振免疫法(FPIA)对口服丙戊酸钠176例、卡马西平72例、苯妥英钠29例的癫痫患者血中药物谷浓度进行监测(277例次),并对其结果进行分析。结果口服丙戊酸钠在有效血药浓度范围内有98例,有效控制率为89.80%;口服卡马西平在有效血药浓度范围内有49例,有效控制率为95.92%;口服苯妥英钠在有效血药浓度范围内有6例,有效控制率为66.67%。结论监测癫痫患者服药后不同时间段体内的血药浓度,对临床及时调整给药方案、降低癫痫的发作率、减少抗癫痫药物的不良反应具有重要意义。

Objective To investigate the relationship among serum concentrations of thee antiepileptics, clinical curative effects and drugs for promoting reasonable clinical application of drugs. Methods With fluorescence polarization immunoassay （FPIA）, valley concentration were monitored for 277 times in 176 cases taking sodium valproate, 72 cases taking carbamazepine and 29 cases taking phenytion sodium. The results were analyzed. Results The valley concentration of sodium valproate was 0.17- 135.68 μg/mL. 98 cases （89.80%） were in effective serum concentration. The valley concentration of carbamazepine was 0.05-13.48 μg/mL, 49 cases （95.92%） were in effective serum concentration. The valley concentration of carbamazepine was 0.24-37.84 μg/mL, 6 cases（66.67% ） were in effective serum concentration. Conclusion Monitoring serum concentration at different time after antiepilitics applied has an important role for adjusting clinical medicine project in time, lowering outbreak of epilepsy, and reducing adverce effects of antiepileptics.