不同雷帕霉素药物洗脱支架在老年冠心病患者中的应用与研究

The application of rapamycin drug-eluting stents in elderly patients with coronary heart disease

目的探讨雷帕霉素药物洗脱支架在老年冠心病经皮冠状动脉介入治疗中应用的安全性和有效性。方法入选320例冠心病患者,分为国产雷帕霉素药物洗脱支架组(Firebird组)160例,进口雷帕霉素药物洗脱支架组(Cypher组)160例。比较两组置入支架后6个月随访时的临床不良事件和再狭窄率。结果Firebird组共置入支架197枚,Cypher组共置入支架204枚。临床6个月随访示Firebird组临床不良事件3例,Cypher组4例,差异无显著性意义。6个月期随访造影显示Firebird组(66例)和Cypher组(77例)支架内再狭窄各出现1例。结论雷帕霉素药物洗脱支架Firebird和Cypher类似,而且Firebird有更高的效价比。

Objective To investigate the feasibility, safety and efficacy of drug-elufing stent implanting in elderly patients with coronary heart disease. Methods 320 coronary heart disease patients were collected and divided into Firebird group （ 160 cases） and Cypher group （ 160 cases）. The incidences of major adverse cardiac events （MACE） and restenosis rates between the two groups were compared 6 months after stenting. Results 197 stents were implanted in Firebird group and 204 stents in Cypher group . After 6 months the incidences of MACE in Firebird group and Cypher group were 3 and 4 cases respectively, with no significant difference. One case of instent restenosis was found in each group by coronary angiography after 6 months. Conclusions The safety and efficacy of Firebird were similar to those of Cypher. Moreover, the cost-effect ratio was higher in Firebird group.