摘要
目的:总结20022004年本院妊娠中期羊水染色体检查及产后随访结果,为今后产前诊断提供经验。方法:原位传代培养羊水细胞并制备染色体,G显带分析核型,产后随访。结果:638例中发现27例异常染色体,其中21-三体2例,18-三体2例,部分21-三体1例,异位5例,倒位8例,嵌合4例。结论对高危妊娠妇女进行羊水染色体核型检查是必须的,开展相关的B超检查及分子诊断,可以进一步提高产前诊断的准确率。
Objective: For better prenatal diagnosis, 638 cases of karyotypes of amniotic fluid cell were retrospectively analyzed and followed up.. Methods: Amniotic fluid cells were cultured in situ and their karyotypes were analyzed by G band, followed them after delivery. Results: 27 abnormal karyotypes were found from 638 case. Among them, there were 2 cases of 21 trisomy, 2 case of 18 trisomy, 1 case of part 21 trisomy, 5 case of translocation, 8 cases of inversion and 4 cases of mosaicism. Conclusion: It is necessary to analysis karyotypes of amniotic fluid cell for high risk gravida , combined with molecule diagnosis can be better to prenatal diagnosis.
出处
《中国妇幼保健》
CAS
北大核心
2007年第2期215-217,共3页
Maternal and Child Health Care of China
关键词
羊水染色体
产前诊断
随访
Karyotypes of amniotic fluid cell
Prenatal diagnosis
Follow up