骨松康胶囊对大鼠绝经后骨质疏松模型的影响

The Effect of Gusongkang Capsule on Rat's Postmenopausal Osteoporosis Model

目的:研究骨松康胶囊对大鼠绝经后骨质疏松模型的治疗作用。方法:将健康雌性SD大鼠32只,随机分成五组:正常组、模型组、西药组、中药组,各8只。除正常组外对其它组大鼠进行摘卵巢手术制造绝经后大鼠模型,术后1周,西药组灌服浓度为5％的尼尔雌醇,每只灌服5ml／周,其它时间灌服等量生理盐水;中药组灌服浓度为20％的骨松康胶囊,每只灌服5ml／日;正常组和模型组每日同时灌服等量生理盐水。投药8周后再次称重,尔后进行摘眼球取血,取左侧股骨。结果:正常组、西药组、中药组与模型组相比,骨密度(BMD)、血清雌二醇(E2)均有显著增高,P<0．01,体重显著降低,P<0．01,正常组、西药组、中药组之间进行比较并无显著性差异P>0．05。结论:骨松康胶囊能够增加去势大鼠BMD、血清E2,降低大鼠体重。

Objective： Aim To study the therapeutical effect of Gusongkang capsule on rat＇s postmenopausal osteoporosis model. Methods： 32 healthy female SD rats were separated ranly 5 groups： normal group, model group,Western medicine group, traditional Chinese medicine group, 8 rats in each group . rat＇s postmenopausal osteoporosis model was established, 1 week later, rats were drenched nilestriol, concentration was 5%, 5ml/week, in Western medicine group, part. aeq isotonic Na chloride was drenched in other time; rats were drenched Gusongkang capsule, concentration was 20%, 5ml/day, in traditional Chinese medicine group; part. aeq isotonic Na chloride was drenched every day in the same time in normal group and model group. After 8 weeks, weighed again, then take blood by removalling eyeball, take left femoral bone. Results： model group compared with other groups, BMD,E2 increased significandy, P〈0.01, weight degraded significandy, P〈0.01, the other three groups have not significant difference P〉0.05. Conclusion： Gusongkang capsule can increase castration rat＇s BMD、E2, degrade rat＇s weight.