心肌再生途径的研究进展

Progress of Studies on Myocardial Regeneration

心急梗塞等心脏疾病可造成心肌的损伤,相继会发生心室扩张、瘢痕、心脏功能紊乱。目前对心脏疾病的治疗主要通过药物和器官移植,因药物治标不治本和移植器官匮乏限制了治疗的效果,严重影响病人的身体健康。最近研究发现,相关细胞因子或基因、干细胞移植可使损伤区心肌细胞和血管再生及诱导内源性干细胞转移,从而修复损伤心肌并恢复心脏功能。以上研究成果及其临床的应用将成为损伤性心肌有效的治疗途径。本文着重阐明了相关细胞因子、基因和干细胞移植对心肌再生作用机制的研究现状。

Heart diseases, such as myocardial infarction, result in myocardial trauma, following ventricular dilatation, scar formation and heart dysfunction, which are now treated by medication and transplant operation.However,both of them are limited. Researchers have recently discovered that relevant genes and cytokines inducement and stem cell transplant could result in cat＇- diomyocytes and vessel regeneration, internal stem cell transfer and heart function resumption, which would become an effective therapy of myocardial infarction of heart disease. The paper has mainly expounded the researches on the effects of related cytokine, genes and stem cell transplant on myocardial regeneration.