高尿酸血症与缺血性卒中

Hyperuricemia and Ischemic Stroke

流行病学研究提示,尿酸水平升高与缺血性卒中风险有直接关系。然而,对于这种关联的意义还存在争议。多数研究结果表明高尿酸血症是发生卒中和卒中转归不良的危险因素,个别研究则提示高尿酸血症对急性缺血性卒中有保护作用。尽管高尿酸血症在卒中病理生理学机制中的作用尚未确定,但通过降低血尿酸水平预防缺血性卒中的干预措施值得考虑。文章主要对最近的临床试验资料和有关机制进行了综述。

Epidemiological studies have suggested that the increase of uric acid level has a direct correlation with the risk of ischenmic stroke. However, the significance of this correlation remains controversy. Most findings have suggested that hyperuricemia is a risk factor for stroke and poor outcome after stroke. Very few studies have suggested that hyperuricemia has protective effect on acute ischenmic stroke. Although the effect of hyperuricernia on pathophysiological mechanisms of stroke remains uncertain, the interventional strategy by lowering the levels of blood uric acid for preventing ischenmic stroke is worth to be considered. This article mainly reviews the recent clinical trials data and related mechanisms.