放射性核素肝胆显像诊断先天性胆道闭锁的临床价值

Clinical Value Of Radionuclide Hepatobiliary Scintigraphy on Diagnosis of Congential Biliary Atresia

目的:回顾性评价99mTc-EHIDA肝胆显像诊断先天性胆道闭锁(BA)的临床价值。方法:应用SPECT仪器对59例临床上持续黄疸的新生儿和婴儿进行99mTc-EHIDA肝胆显像,并经手术病理诊断及随访确诊。结果:最终诊断为BA的34例患儿中,99mTc-EHIDA肝胆显像全部检出;非BA组25例中23例为真阴性,2例为假阳性,灵敏度为100%,特异性92%,准确度96.6%。结论:99mTc-EHIDA肝胆显像是一种无创、安全、有效的检查方法,有助于明确病因,预测治疗效果,对于BA的诊断有较高的临床价值。

Objective To retrospectively evaluate the diagnostic value of 99 mTe-EHIDA hepatobiliary seintigraphy in eongential biliary atresia（BA）. Methods Forty-nine infants and neonates （34 infants＂ with BA, the other 25 with non--BA）with consistent jaundice received 99 mTe-EHIDAhepatobiliary seintigraphy with SPECT instrument, the results of all patients were proved by pathology and clinical follow-up results. Results 99 mTe-EHIDA hepatobiliary seintigraphy diagnosed 34 infants and neonates with last diagnosis BA correctly ;23 infants and neonates with last diagnosis non-BA correctly, but 2 neonates false- positive in all non-BA 25 patients. The sensitivity,specificity and correct rate of this method were 100% ,92% and 96.6% ,respectively. Conclusion 99 mTc-EHIDA hepatobiliary scintigraphy is an anoninvasive, safety, valuable examing method. It will help us definite the etilogy, predict the therapeutic efficacy, and have high clinical value in the diagnosis of BA.