摘要
目的确定一种新的呋喃妥因合成工艺.方法以糠醛、1-氨基海因盐酸盐、浓硫酸、硝酸为原料,选择适当的混酸浓度,并用DMF重结晶制得呋喃妥因.结果符合《中国药典》2005年版质量要求.结论本工艺收率较高,成本相对较低,产品质量稳定并符合法定标准.
OBJECTIVE To establish a new synthetic route of Nitrofurantoin, METHODS Nitrofurantoin was used furfural, 1-aminohydantoin hydrochloride,concentrated sulfuric acid and nitric acid as raw material,and choose a suitable concentration of the mixed add,then recrystallized with DMF, RESULTS The product quantity complied C. P. 2005. CONCLUSION The method has a high yield and a low cost,The product quantity is stable and complied the lawful standard.
出处
《齐鲁药事》
2007年第1期43-44,共2页
qilu pharmaceutical affairs
关键词
呋喃妥因
抗菌药
合成
1-氨基海因盐酸盐
糠醛
nitrofurantoin
antibacterial
synthesis
1-aminohydarxtoin hydrochloride
furfural
