佐芬普利的合成工艺研究

Study on the Synthetic Technique of Zofenopril

本文报道了一条简便的佐芬普利合成方法,在中间体的合成过程中,无需进行结晶纯化。采用二环己胺对佐芬普利酸进行拆分,收率达36%。该方法能较大程度上简化操作步骤,避免了对侧链进行拆分时烦琐的重结晶过程和使用价格昂贵的拆分剂。

Herein we report a simple route to the synthesis of zofenopril, the purification processes of intermediates were avoided. The splitting of zofenopril was gained by zofenopril free acid forming salt with dicyclohexylamine. This novel method can avoid complicated recrystallization processes, and expensive separator, the yield is as high as 36%.