精神病患者血清瘦素、脂联素检测的意义

The significance of serum leptin and adiponectin determination in patients with psychosis

目的 探讨血清瘦素、脂联素（Adi）在精神病患者治疗前后的含量变化及其与抗精神病药源性肥胖的关系。方法 用放射免疫、电化学发光分析法测定62名健康体检人员和125例精神病患者血清瘦素、Adi、胰岛素（INS）的水平。结果 男性患者血清瘦素为（4．79±2．69）μg/L，女性为（7．78±3．61）μg/L，与对照组比较显著升高（P〈0．05）。Adi女性患者组为（6．43±3．60）mg／L，显著低于对照组（P〈0．05），男性组虽有降低但差异无统计学意义（P〉0．05）。治疗后血清瘦素较治疗前明显升高且差异有统计学意义（P〈0．05～0．01），Adi显著低于治疗前（P〈0．01）。结论 应用抗精神病药物治疗后，瘦素水平随体重的增加而增高，Adi随体重的增加而降低。

Objective To investigate the relationship between the change of serum leptin and adiponectin（Adi） in patient with psychosis before and after treatment and the adiposity induced by antipsychotic agents. Methods The levels of leptin, Adi and insulin（INS） in 125 patients with psychosis and 62 health controls were determined by radio immunoassay and electrochemi-luminescence immunoassay. Results The level of leptin was （4.79 ±2.69）μg/L in male patients and （7.78 ± 3.61 ） μg/L in female patients. As compared to controls, the level of leptin in patients increased significantly （ P 〈 0.05 ）. The level of Adi in female patients [ （ 6.43 ± 3.60 ） mg/L ] was much lower than that in controls （ P 〈 0.05 ） and there was no significant difference between male patients and controls （ P 〉 0.05 ）. After treatment, the level of leptin increased（P 〈0.05 -0.01） and Aid decreased（P 〈0.01）. Conclusions After treatment by antipsychotic agents, the level of leptin increases and the level of Adi decreases together with the gain of body weight.