RT-Q医用生物膜的止血及生物相容性研究

Study of hemostatic effect and biocompatibility of RT-Q-remedial biomembrane

目的：研究RT-Q医用生物膜（以下简称RT-Q膜）的术中局部止血作用及其生物相容性。方法：通过比较RT-Q膜、瞬康医用胶（以下简称瞬康胶）、附加剂、阴性对照对大鼠颈外静脉切口出血时间和出血量的影响，研究其术中止血效果；通过观察大鼠后肢肌肉切开用此膜后对伤口愈合、生物膜降解及周围组织是否有毒性影响等情况评价其生物相容性。结果：与阴性对照组、附加剂组比较，RT-Q膜组止血效果显著（P〈0．01），与瞬康医用胶组比较无统计学意义；RT-Q膜对伤口愈合既无促进也无延迟性影响，形成的膜于术后15d开始降解，3～4周完全吸收，对周围组织无毒性影响。结论：RT-Q医用生物膜的局部止血效果显著、且具有生物相容性。

AIM： To investigate the hemostatic effect and biocompafibility of RT-Q-remedial biomembrane. METHODS： There were control, excipient, Shunkang and RT-Q group in topical bleeding experiment and control, excipient, and RT-Q group in topical biocompatibility experiment, in order to study the hemostatic effect on jugular vein of rat, and to observe the biodegradability and histocompatibility of RT-Q in muscle of rat legs. RESULTS： The hemostatic effect is significant compared with control group and excipient group （P 〈 0.01）, but there is no significant difference compared with Shunkang group （ P 〉 0.05）. The biological evaluation for the biocompatibility is excellent. CONCLUSION： The significant hemostatic effect and good biocompatibility have been proved in topical bleeding of RT-Q.