摘要
中国胃癌的发病例数占全球总数的1／3。化疗是治疗胃癌的有效手段，但由于肿瘤细胞多药耐药性（MDR）的产生，化疗疗效往往不佳。深入探讨胃癌MDR产生机制，寻找有效低毒的多药耐药逆转剂，对提高化疗的有效性，延长患者的生存期有着重要的意义。从转运蛋白有关的耐药机制、酶系统有关的耐药机制、细胞凋亡与耐药、细胞因子等四方面肿瘤细胞MDR产生的机制做一简要综述。
The incidence of gastric carcinoma in our country has objected to one-third in all globe. The effective means to treat gastric carcinoma is chemical theraty, but because of production of tumor cells muhidrug resistance, ＇ effeetion of chemical therapy is not very good. Explore gastric carcinoma MDR mechanism, find low poison and highly efficient MDR reversal agents have more important significance for improving chemical therapeutic effectiveness, prolonging sickness survival time. Now, four mechanisms about tumor ceils multidrug resistance are summaried such as transport protein,enzyme system,programmed Cell death and cytokine.
出处
《肿瘤研究与临床》
CAS
2007年第1期68-70,72,共4页
Cancer Research and Clinic
关键词
胃肿瘤
抗药性
多药
多药耐药相关蛋白质类
反转录酶抑制剂
Gastric cancer
Drug resistance, Multiple
Multidrug resistance-Associated proteins
Reverse transcripase inhibitors
