摘要
OBJECTIVE: To investigate the structure, location, function and regulation of Zonula occluden-1 (ZO-1) as well as the correlation of ZO-1 with diseases for helping diagnosis, treatment and determining prognosis of correlative diseases. DATA SOURCES : Using the terms "Zonula Occluden", we searched the Medline database to identify ZO-1 related articles published between May 1963 and December 2006 in English. STUDY SELECTION : The articles were selected firstly, and those involved the structure, location, function and regulation of ZO-1 as well as the correlation of ZO-1 with diseases were chosen. The full texts of the left articles were searched. Inclusive cnteda: Studies associated with the structure, location, function and regulation of ZO-1 as well as those associated with the correlation of ZO-1 with diseases. Exclusive cnteria: Studies with repetitive or uncorrelated contents. DATA EXTRACTION : Among 1 462 collected articles of ZO-1, 1 424 were excluded. Of the 38 articles, which met inclusive criteria, 11, 2, 10, 11 and 4 were associated with the structure, location, function and regulation of ZO-1 as well as the correlation of ZO-1 with diseases, respectively. DATA SYNTHESIS: ZO-1 is a member of membrane associated guarylate kinasellike proteins (MAGUKS), can not form homooligomers and exists as ZO-1/ZO-2 and ZO-1/ZO-3 heterodimers. It is expressed in endothelial cells and epithelial cells and also in other types (except for tight junction) of cells. It exists not only in tight junction but also in adherens junction. " Messenger" which contacts with various junctional complexes, interacts with tight junction, adherens junction and gap junction to maintain the structure and function of junctional complex. The structure and function of ZO-1 are regulated by many factors, such as Ca^2+, phosphorylation, protein kinase C, G protein and so on. ZO-1 plays an important role in the treatment of ischemia/hypoxia, inflammation and tumors. CONCLUSION: ZO-1, which is only used as a tight junction protein initially, has been found to be a "messenger" which can contact various junctional complexes, interacts with tight junction, adherens junction and gap junction and is related with the pathogenesis of many diseases.
OBJECTIVE: To investigate the structure, location, function and regulation of Zonula occluden-1 (ZO-1) as well as the correlation of ZO-1 with diseases for helping diagnosis, treatment and determining prognosis of correlative diseases. DATA SOURCES : Using the terms "Zonula Occluden", we searched the Medline database to identify ZO-1 related articles published between May 1963 and December 2006 in English. STUDY SELECTION : The articles were selected firstly, and those involved the structure, location, function and regulation of ZO-1 as well as the correlation of ZO-1 with diseases were chosen. The full texts of the left articles were searched. Inclusive cnteda: Studies associated with the structure, location, function and regulation of ZO-1 as well as those associated with the correlation of ZO-1 with diseases. Exclusive cnteria: Studies with repetitive or uncorrelated contents. DATA EXTRACTION : Among 1 462 collected articles of ZO-1, 1 424 were excluded. Of the 38 articles, which met inclusive criteria, 11, 2, 10, 11 and 4 were associated with the structure, location, function and regulation of ZO-1 as well as the correlation of ZO-1 with diseases, respectively. DATA SYNTHESIS: ZO-1 is a member of membrane associated guarylate kinasellike proteins (MAGUKS), can not form homooligomers and exists as ZO-1/ZO-2 and ZO-1/ZO-3 heterodimers. It is expressed in endothelial cells and epithelial cells and also in other types (except for tight junction) of cells. It exists not only in tight junction but also in adherens junction. " Messenger" which contacts with various junctional complexes, interacts with tight junction, adherens junction and gap junction to maintain the structure and function of junctional complex. The structure and function of ZO-1 are regulated by many factors, such as Ca^2+, phosphorylation, protein kinase C, G protein and so on. ZO-1 plays an important role in the treatment of ischemia/hypoxia, inflammation and tumors. CONCLUSION: ZO-1, which is only used as a tight junction protein initially, has been found to be a "messenger" which can contact various junctional complexes, interacts with tight junction, adherens junction and gap junction and is related with the pathogenesis of many diseases.