摘要
目的研究牛初乳冻干粉对预防酒精肝损伤的作用。方法受试组灌胃牛初乳冻干粉(350 mg/kg)30 d,第30天时,与模型组同时灌胃50%乙醇(12 mL/kg),对照组灌胃等量的蒸馏水,且不服用酒精,禁食12 h后处死小鼠。取左叶肝测试生化指标,并取样固定后制作肝病理切片。结果受试组与酒精模型组谷胱甘肽(GSH)、高密度脂蛋白胆固醇(HDL-C)提高,差异显著(P<0.05与P<0.01),但受试组甘油三酯(TG)较模型组高,有待研究。肝病理切片显示模型组肝脂肪变性损伤评分值较对照组高达4.5倍,而牛初乳冻干粉受试组与对照组评分值相似。结论牛初乳冻干粉具有预防酒精肝损伤的效果。
Objective To study the defend function of lyophilized bovine colostrums on alcohol liver injury in mice. Methods Objective Lyophilized Bovine Colostrums （350 mg/kg） 3 d. The alcohol model group also used 50% alcohol（12 mL/ kg） together. The control group only used distilled water. The experiment tested biochemistry and alcohol liver injury in adipose. Results The Lyophilized Bovine Colostrums group and alcohol model group GSH, HDL-C increased significant and deceased The content of MDA, Its protect effect was also proved by liver patholgical changes in total score. Conclusion Lyophilized Bovine Colostrums had protectived effect on alcohol liver injury.
出处
《中国比较医学杂志》
CAS
2007年第1期33-35,F0003,共4页
Chinese Journal of Comparative Medicine
关键词
牛初乳冻干粉
酒精
酒精性肝损伤
Lyophilized Bovine Colostrums
Alcohol
Alcohol Liver Injury.
