COX-2、VEGF在NSCLC中的表达及与微血管生成的关系

Expression of COX-2 and VEGF in NSCLC and its relationship with angiogenesis

目的探讨肺癌组织中COX-2、VEGF的表达及与血管生成和临床病理特征的关系。方法收集85例肺癌和20例肺良性病变标本,免疫组化S-P法检测COX-2、VEGF蛋白及MVD的表达并作相关分析。结果COX-2、VEGF、MVD在肺癌中的阳性表达率显著高于肺良性病变组织(P<0.05);COX-2表达与肺癌的组织学类型、分化程度和淋巴结转移相关(P<0.05);VEGF表达与肺癌分化程度和淋巴结转移相关(P<0.05);COX-2、VEGF、MVD呈两两正相关。结论COX-2、VEGF参与了肺癌的发生发展过程,COX-2可能通过上调VEGF促进肺癌的血管新生和发生发展。

Objective： To investigate the expression of COX -2 and VEGF in NSCLC and its relationship with tumor angiogenesis. Methods： Total of 85 specimens of lung cancer and 20 specimens of lung benign lesion were collected,immunohistochemistry was ased to examine the expression of COX -2, VEGF and MVD. Results： The positive rate of COX - 2, VEGF and MVD expression in NSCLC were all significantly higher than that in lung benign lesion. The expression of COX -2 was positively correlated with histological type, differentiation degree and lymph node metastasis of NSCLC （P 〈 0.05 ）. The expression of VEGF was positively related with tumor differentiation degree and lymph node metastasis （ P 〈 0.05 ）. There was statistically significant correlation between the expression of COX -2, VEGF and MVD. Condusion： The high expression of COX -2 and VEGF are involved in lung cancer development. COX -2 may upregulate VEGF expression, thus promote angiogenesis and lung cancer development.