绝经后乳腺癌雌、孕激素受体状态与血清性激素水平的关系

Association of serum sex hormone levels with the expression of estrogen and progesterone receptors in postmenopausal patients with breast cancer

目的探讨绝经后乳腺癌雌激素受体(ER)、孕激素受体(PR)状态与患者血清性激素水平的关系及意义。方法使用全自动免疫分析仪化学发光分析法检测41例乳腺癌患者血清性激素六项(LH、FSH、PRL、E2、P、T)水平,免疫组化EnVision二步法检测乳腺癌ER、PR表达状态。结果绝经后乳腺癌PR阴性组与PR阳性组比较,患者血清LH、FSH水平显著增高(P值分别为0.005和0.031),PRL、E2、P、T水平在二组间差异无统计学意义;在ER阴性组与ER阳性组之间所测性激素水平差异无统计学意义。结论绝经后乳腺癌PR表达状态可能与垂体激素LH、FSH水平有关。

Objective： To investigate the relationship between serum sex hormone levels and the status of estrogen and progesterone receptors in postmenopausal patients with breast cancer and it＇s clinical significance. Methods： The levels of luteinizing hormone LH, follicle - stimulating hormone FSH, prolactin PRL , estrodion E2, progesterone P and testosterone T in serum were measured with chemiluminescence immunoassay and the estrogen and progestorue receptors were deteced by immunohistochemistry in 41 cases of postmenopausal breast cancer patients. Results： The levels of LH and FSH were significantly higher in the PR positive breast cancer group than those in the PR negative group（ P = 0.005and P = 0.031, respectively） , no significant differences were found between the two groups in the levels of PRL, E2, P, and T. The levels of LH, FSH, PRL, E2, P and T were not significantly different between the ER positive breast cancer group and the ER negative group. Conclusion： The status of PR, may be associated with the levels of LH, FSH in postmenopausal breast cancer patients.