晚期卵巢癌化疗联合放疗的临床研究

Clinical study on advanced ovarian cancer by chemotherapy combined with radiotherapy

目的：探讨化疗联合放疗综合治疗晚期卵巢癌的疗效和毒性。方法：随机将不能手术的晚期卵巢癌患者分为两组，即化疗组和化放疗组，两组各36例，均使用IPA方案，IF01．2g／m^2，i．vdripd1～5，Mesna0．4gi．v（0、4、8h）d1～5，DDP60～80mg／m^2，i．vd1，ADM40～60mg／m^2，i．vd1。化疗组用该方案连续化疗3个周期，每3周重复1次；化放疗组先用该方案化疗1周期，接着用6MV—X线全盆腔外照射DT40GY／dW，再缩野至癌灶局部加量DT10～20GY／1～2W，放疗结束后，休息1周，再化疗2个周期，每3周重复1次。结果：化疗组和化放疗组有效率（CR＋PR）为77．8％和100％，1、3年生存率分别为60．1％，32．7％和73．1％，48．2％。毒性反应：以骨髓抑制和消化道反应为主。结论：化疗联合放疗综合治疗晚期卵巢癌能提高局控率和生存率，且并发症发生率较低，是一种安全、有效、较理想的治疗方法。

Objective： To study the effect and side effect of advanced ovarian cancer treated by chemotherapy combined with radiotherapy. Methods： Seventy two cases of advanced ovarian cancer can not accepted operation were divided into 2 groups. Group 1 received chemotherapy,treated by IPA 3 times, 3 weeks a circle. Chemotherapy combined with radiotherapy was given to Group 2, treated by IPA 1 times , all pelvis field accepted radiotherapy （6MV - X Ray） DT40GY/4W,thenreduced the field and dosage to DT10 - 20GY/1 -2W. Chemotherapy was given after a week,3 weeks a circle. Results： The efficient rate （ CR ＋ PR） were 77.8% and 100% respectively. 1,3 years survival rate were 60.1% ,32.7% and 73.1% ,48.2%. Side effects included prolonged nausea and vomiting,leukopenia. Conclusion： Chemotherapy combined radiotherapy may increased local control rate and survival rate . The side effect was lower. It is a safe and efficient therapy for advanced ovarian cancer.