^(153)钐-乙二胺四亚甲基膦酸治疗骨转移瘤的疗效观察

Clinical observation of the treatment for bone metastases with ^(153)Sm-EDTMP

目的观察153钐-乙二胺四亚甲基膦酸(153钐-EDTMP)治疗骨转移瘤的疗效。方法对96例骨转移瘤患者给予剂量范围为18.5~55.5MBq/kg的153钐-EDTMP治疗。结果患者疼痛总缓解率为86.5%(83/96);影像学显示部分患者骨转移灶缩小、消失、减少或病灶处浓聚减弱。不良反应主要为骨髓抑制,经治疗2周~4周内皆能好转恢复。结论153钐-EDTMP对转移性骨肿瘤有明显缓解骨痛、控制病情进展的作用,使用安全。

Objective： To evaluate ^153 Sm- EDTMP therapy for patients with bone metastases of malignant tumor. Methods： Total of 96 patients with bone metastases were treated with ^153 Sm -EDTMP injected into the veins, 18.5 -55.5MBq/kg. Results： The total response rate was 86.5% （83/96）. Bone metastases of some patients diminished or disappeared. The main side - effect was temporary myelosuppression, which could been cured in 2 or 4 weeks after treatment. Conclusion： Therapy of intravenous injection samarium- 153 is effective method to relieve metastatic cancer bone pain and to control the disease.