急性早幼粒细胞白血病处理中的共识和争议

Current consensus and controversies of acute promyelocytic leukemia treatment

急性早幼粒细胞白血病的正确处理包括如下方面使用全反式维甲酸和蒽环类为基础的化疗联合治疗,恰当的支持治疗,从细胞和分子遗传水平证实诊断,正确分析治疗反应及通过分子监测评估疾病复发的危险性。本文综述初治APL患者现代处理方法,并提出一些尚有争议的问题供探讨。

Modern management of acute promyelocytic leukemia（APL） implied the use of the start - of - the - art regimen including all - trans retinoic acid and anthracycline chemotherapy, the adoption of appropriate supportive measures, rapid establishment of an accurate genetic diagnosis, correct assessment of response to therapy and evaluation of the risk of disease recurrence by molecular monitoring. This article reviews the current standard practices and controversial issues in the treatment of patients with newly diagnozed APL.