肺癌病人外周血单核细胞IL－1水平研究

STUDY ON THE LEVELS OF INTERLEUKIN-1 OF PERIPHERAL BLOOD MONONUCLEAR CELLS IN PATIENTS WITH LUNG CANCER

测定了２５例肺癌病人外周血单位细胞（ＰＢＭＣ）白细胞介素上（ＩＬ－１）水平及ＰＢＭＣ对大肠杆菌脂多糖（ＬＰＳ）、二氧化硅（ＳｉＯ２）的反应性，结果表明，肺癌病人ＩＬ－１水平在刺激前后均显著高于正常人（Ｐ＜０．００１～０．０１），且这种差异不受化疗因素的影响。ＰＢＭ细胞对ＬＰＳ、ＳｉＯ２的反应性比正常人稍低，但统计学分析无显著差异。提示肺癌病人ＩＬ－１增高是机体抗肿瘤免疫反应之一，与病人的细胞因子网络状态有关，对肺癌的诊断有一定的临床价值。

The interleukin-1(IL-1) activity produced by peripheral blood mononuclear cells(PBMC)and PBMC reactivity to lipopolysaccharide(LPS)and Silica(SiO2)in 25 cases of lungcancer and 22 normal controls were examined and analyzed. The result showed that the IL-1levels of the paticnts are all significantly higher than that of normal controls before and afterstimulation(P<0. 001～0. 01),This differencc is not affected by chemotherapy. The reactivityof PBMC to LPS and SiO2 in the patients tended to decrease than that of normal controls but thestatistical data showed no significant difference. The high IL-1 activity of PBMC is one of thebody antineoplastic immune responses in lung cancer. This is related to their state of cytokinessystem. The results may be of value to some extent in the diagnosis of lung cancer.