胃癌患者血清sIL－2R测定的临床价值

THE CLINICALVALUE OF MEASURING THE SERUM LEVEL OF SOLUBLE INTERLEUKIN-2 RECEPTOR IN PATIENTS WITH GASTRIC CANCER

应用双抗加心法对７８例胃癌患者血清可溶性白介素２受体（ｓＩＬ－２Ｒ）进行临床研究。结果发现：胃癌患者ｓＩＬ－２Ｒ水平明显高于胃良性疾病患者和正常人（Ｐ＜０．０１）；Ⅲ、Ⅳ期高于Ⅰ、Ⅱ期（Ｐ＜０．０５）；手术切除后（根治或姑息）ｓＩＬ－２Ｒ显著下降（Ｐ＜０．０１）；手术后复发和转移患者血清ｓＩＬ－２Ｒ升高（Ｐ＜０．０１）；如果患者血清ｓＩＬ－２Ｒ高于１０００Ｕ／ｍｌ，生存期短。提示胃癌患者ｓＩＬ－２Ｒ水平高低与肿瘤分期、手术方式、复发转移和预后有关，监测胃癌患者血清ｓＩＬ－２Ｒ水平对临床病情和预后有重大意义。

The serum soluble interleukin-2 receptor(sIL-2R)in 78 paticnts with gastriccancer was measurred by sandwich ELISA with monoclonal and polyclonal antibodies techniquebefore and after opcration. The data showed that the serum level of slL-2 R was significantlyhigher than that of healthy controls and benign gastric diseases in both groups(P<0. 01).Theserum level of slL-2R was highcr in stage Ⅲ,Ⅳ than that in stageⅠ,Ⅱ(P<0.05),and theserum level of slL-2R was remarkably declined in the postoperative group(including both radicaloperation and palliative tumor resection)(P<0. 01).An obvious clcvation of serum level of slL-2R was also observed in patients with recurrence and metastasis of carcinoma after tumor removal(P<0.01).If the concentration of serum slL-2R was more than 1,000 u/ml, the prognosis ofthe patients was poor. This results indicated that the serum level of slL-2R in gastric cancerpatients was connected with gastric cancer stage,operation method and late results,andrecurrence and mestastasis of carcinoma after tumor resection,Monitoring serum level of sIL-2Rhas clinical significance in discase activity and prognosis in patients with gastric cancer.