2005年合肥地区健康人群流脑带菌状况调查及分析

Investigation and Analysis of Neisseria meningitides Infection Status of Residents in Hefei District

目的了解合肥地区健康人群流脑带菌状况,为制订防控措施提供依据。方法于流脑流行前期采集不同人群咽拭子于卵黄双抗琼脂培养基进行脑膜炎奈瑟氏菌分离培养。结果不同人群共采集标本1047份,检出阳性32份,阳性率3.06%;菌株分别为A,B,C,H,29E群,其中B,C群各占34.4%。高中生组流脑带菌率最高,为6.67%,经统计学检验,与小学生及幼儿组阳性带菌率有显著性差异。男性带菌率3.89%,女性带菌率2.07%,差异无统计学意义;城区人群带菌率2.17%,农村人群带菌率4.24%,差异无统计学意义。结论合肥市健康人群流脑带菌率较低,高中生组人群中流脑带菌率较高。要警惕C群流脑菌群引起的流行,进一步探讨B群带菌率增多的流行病学意义。

Objective To understand Neisseria meningitides infection status of residents in Hefei district. Methods Throat swab specimens were collected from residents before epidemic cerebrospinal meningitis periods in December 2005 and cultured on EPV media. Results 32 strains including group A, B, C, H, E of N. meningitides were isolated from 1047 specimens. The positive rate of N. meningitides was 3.01%. Group B, C accounted for 68.7 %. Carrier rate of high school students was 6.67%, ranked the first. There was significant difference between high school students and students in elementary school and kindergarten. The carrier rate of male and female was 3.9% and 2.1% respectively. The rate of students in urban and rural area was 2.17% and 4.24% respectively. There were no significant difference between two sexes and two regions. Conclusion The data suggested that carrier rate of N. meningitides was low in Hefei district. Carrier rate was higher in high school students. We should pay more attention to B and C groups.