内皮蛋白C受体、加强蛋白C与肺部疾病的关系

Relationship of endothelial protein C receptor and activated protein C with pulmonary diseases

内皮蛋白C受体（EPCR）是新近分离纯化的蛋白，作为蛋白C抗凝系统中新的一员，其在加强蛋白C（APC）活化和调节炎症反应方面有着重要作用。EPCR介导的活化的PC在急性肺损伤、肺纤维化和支气管哮喘等肺部炎症性疾病中具有重要意义，是未来研究的方向之一。

Endothelial protein C receptor （EPCR）,as one of the components of the protein C pathway which provides a natural anti-coagulant feedback mechanism, has recently been dissociated and depurated. It plays an important role in augmentation of protein C activation and regulation of inflammatory reaction. Activated protein C （APC） contributes not only anti-coagulant activity but also antipoptotic and antiinflammatory functions,which are dependent on EPCR. APC and EPCR may have important significance in many pulmonary inflammatory diseases such as acute lung injury, fibrosis and bronchial asthma. The functions of EPCR may be one of the investigation aspects in the future.