期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

氧自由基在肺缺血再灌注损伤中的作用机制 被引量：24

Effect of oxygen free radicals on lung ischemia-reperfusion injury
原文传递
导出
摘要 凡是具有未成对电子的原子、分子或原子团都称为自由基，在体内分布广泛。氧自由基的直接损伤作用、以及在介导脂质过氧化、蛋白质和DNA损伤、改变信号传导通路、刺激转录因子活化以及诱导细胞凋亡中有重要而广泛的生物学效应，对肺缺血再灌注损伤的发生、发展和转归有着重要的影响。 All unpaired atom,molecule and atomic group are called free radicals,which exist in body widely. Oxygen free radicals have direct injury function, and important biologic effect leading to lipid peroxidation, damage of protein and DNA, change of signal pathway, stimulating transcriptional factor activation,inducing cell apoptosis. Oxygen free radicals have important influence in occurrence, developtment and turnover in lung ischemia-reperfusion injury.
作者 井军虎 李建强
机构地区 山西医科大学第二医院呼吸内科
出处 《国际呼吸杂志》 2007年第2期114-117,共4页 International Journal of Respiration
关键词 氧自由基 缺血再灌注 肺损伤 Oxygen free radical Ischemia-reperfusion Lung injury
分类号 R563 [医药卫生—呼吸系统]
  • 相关文献

参考文献26

  • 1仝文,吴培云.氧自由基与新生儿肺损伤[J].中国煤炭工业医学杂志,2004,7(5):389-390. 被引量：6
  • 2Hoffman J,Johausen A,Steiro K,et al.Chitooligosaccharides stimulate atlantic salmou,salmo salar L,head kidney leukocytes to enhanced superoxiode anion production in vitro.J Biol Chem,1997,118:105-115.
  • 3van der Vliet A,Cross CE.Oxidants,nitrosants,and the lung.Am J Med,2000,109:398-421.
  • 4Zamora CA,Baron DA,Heffner JE,et al.Thromboxane contritutes to pulmonary hypertension in ischemia/reperfusion lung injury.J Applphysiol,1993,74:224-229.
  • 5Ardekani RG,Faber LP,Beattie EJ,et al.Pulmonary function after various periods of ischemia in the lung.J Thorac Cardiovasc Surg,1970,59:607-612.
  • 6王晓杨.肺缺血再灌注损伤中细胞因子的作用[J].医学理论与实践,2005,18(3):251-253. 被引量：16
  • 7陈志新.中性粒细胞在肺缺血再灌注损伤中的作用[J].国外医学（麻醉学与复苏分册）,2002,23(3):176-179. 被引量：9
  • 8Linder N,Rapola J,Raivio KO.Cellular expression of xanthine oxidoreductase protein in normal human tissue.Lab Invest,1999,79:967-974.
  • 9Haddad JJ,Olver RE,Land SC.Antioxidant/pro-oxidant equilibrium regulates HIF-1α and NF-κB redox sensitivity:evidence for inhibition by glutathione oxidation in alveolar epithelial cells.J Biol Chem,2000,275:21130-21139.
  • 10徐金富,瞿介明,何礼贤.肺部感染相关急性肺损伤发病机制研究进展[J].国外医学（呼吸系统分册）,2004,24(2):72-75. 被引量：13

二级参考文献91

  • 1Lesur O,Kokis A, Hermans C,et al. Interleukin-2 involvement in early acute respiratory distress syndrome: relationship with polymorphonuclear neutrophil apoptosis and patient survival.Crit Care Med,2000,28:3814-3822.
  • 2Pacht ER,DeMichele SJ,Nelson JL,et al. Enteral nutrition with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants reduces alveolar inflammatory mediators and protein influx in patients with acute respiratory distress syndrome. Crit Care Med,2003
  • 3Haddad JJ, Olver RE, Land SC: Antioxidant/pro-oxidant equilibrium regulates HIF-1α and NF-κB redox sensitivity:evidence for inhibition by glutathione oxidation in alveolar epithelial cells. J Biol Chem,2000,275:21130-21139.
  • 4Parsey MV,Kaneko D,Shenkar R,et al. Neutrophil apoptosis in the lung after hemorrhage or endotoxemia: apoptosis and migration are independent of interleukin-1beta. Chest, 1999,116: 67S-68S.
  • 5Abraham E,Kaneko DJ,Shenkar R. Effects of endogenous and exogenous catecholamines on LPS-induced neutrophil trafficking and activation. Am J Physiol, 1999,276: t1 8.
  • 6Wilkinson TM,Patel IS, Wilks M, et al. Airway bacterial load and FEV1 decline in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 2003,167:1090-1095.
  • 7Martin GS, Mannino DM, Eaton S, et al. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med, 2003,348: 1546-1554.
  • 8Yokomura I, Iwasaki Y, Nagata K, et al. Role of intercellular adhesion molecule 1 in acute lung injury induced by candidemia.Exp Lung Res,2001,27:417-431.
  • 9Scapini P,Lapinet-Vera JA,Gasperini S,et al. The neutrophil as a cellular source of chemokines. Immunol Rev, 2000, 177: 195-203.
  • 10Kobayashi SD, Voyich JM, Braughton KR, et al. Downregulation of proinflammatory capacity during apoptosis in human polymorphonuclear leukocytes. J Immunol, 2003, 170:3357-3368.

共引文献75

同被引文献171

引证文献24

二级引证文献84

国际呼吸杂志
2007年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部