摘要
目的观察参附注射液对大鼠离体心脏缺血再灌注损伤的保护作用。方法采用Langendorff大鼠离体心脏灌流技术制备心脏缺血再灌注损伤模型,用不同浓度氮饱和参附注射液灌流心脏。观察记录复灌20min和40min时的心率,灌流量及酶指标的变化。结果参附注射液可提高心脏缺血再灌期的心率和冠脉流量,明显降低灌流液中乳酸脱氢酶(LDH)、肌酸激酶(CK)的水平。结论参附注射液对缺血再灌注损伤心脏具有保护作用。
Objective To observe the cardioprotective effect of ginseng - monkshood extract injection on ischemia - reperfusion injury in rats＇ isolated working hearts. Methods The heart models of ischemia - reperfusion injury were built by Langendorff isolated heart perfusion technology. The different concentrations of nitrogen saturated Ginseng - monkshood extract injection were used for infusion, and the indexes of heart rate, coronary flow and myocardial enzymes were observed in reperfusion 20 min and 40 min. Results Infusion of ginseng - monkshood extract injection can improved heart rate and flux of coronary artery and inhibit the leak of lactic dehydrogenase and creatine kinase during ischemia reperfusion. Conclusions Ginseng - monkshood extract injection has obviously protective effect on myocardial ischemia reperfusion injury.
出处
《中药新药与临床药理》
CAS
CSCD
2007年第1期17-19,共3页
Traditional Chinese Drug Research and Clinical Pharmacology
关键词
参附注射液
离体心脏灌流
心肌酶
大鼠
Ginseng - monkshood extract
Isolated heart reperfusion
Myocardial enzyme
Rat
