人参皂苷Re促进自然衰老大鼠学习记忆作用及其机理的研究

Improvement Effect of Ginsenoside Re on Learning and Memory Abilities of Natural Apolexis Rats and Its Mechanisms

目的研究人参皂苷Re对自然衰老大鼠学习记忆功能的影响,并初步探讨其作用机制。方法采用Morris水迷宫法观察人参皂苷Re对大鼠学习记忆功能的影响,同时采用电生理学方法观察人参皂苷Re对大鼠突触长时程增强(LTP)的作用。结果人参皂苷Re能显著对抗自然衰老引起的记忆获得障碍,对麻醉大鼠海马齿状回基础突触传递有增强作用,且能形成突触长时程增强形象。结论人参皂苷Re有改善大鼠学习记忆障碍的作用,该作用可能与其增强基础突触传递、促进LTP形成有关。

Objective To study the influences of ginsenoside Re on learning and memory abilities of natural apolexis rats and to probe its preliminary mechanism. Method Water maze test for old rats was used to observe the effect of ginsenoside Re on learning and memory, and electrophysiological technique to record the long -term potentiation（LTP） in basic synaptic transmission of the dentate gyrus in anesthetized rats. Results Ginsenoside Re can markedly counteract memory acquisition impairment in natural apolexis rats, and enhance the synaptic transmission in the dentate gyrus and form the LTP consequence. Conclusion Ginsenoside Re can improve the learning and memory obstacle in rats , the mechanism may correlate with its enhancing the basic synaptic transmission and promoting the magnitude of LTP of the dentate gyrus.