黄连素联合格列吡嗪对2型糖尿病治疗效果的研究

Therapeutic Efficacy of Combined Berberine and Glipizide on Type 2 Diabetes

【目的】研究黄连素与格列吡嗪联合应用对2型糖尿病的降糖作用、临床疗效及毒副作用。【方法】152例2型糖尿病患者随机分成3组,分别给予格列吡嗪、黄连素及格列吡嗪和黄连素,在治疗后不同时间对患者进行空腹血糖、胰岛素、C肽、糖化血红蛋白、甘油三酯、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇及餐后2 h血糖测定,以评价这些处理措施对2型糖尿病的治疗效果。【结果】三种处理方法均能有效降低空腹血糖及餐后2 h血糖;但格列吡嗪与黄连素联合应用可明显提高治疗有效率(与格列吡嗪组和黄连素组比较,P<0.05)。单独应用格列吡嗪对血脂代谢无影响,但对胰岛素抵抗有一定改善;单独运用黄连素或将黄连素与格列吡嗪联合应用不但能有效改善患者胰岛素抵抗,恢复患者胰岛功能,患者的血脂代谢异常也出现了明显的改善。联合应用黄连素与格列吡嗪未发现明显的毒副作用。【结论】黄连素与格列吡嗪联合应用治疗2型糖尿病具有良好的协同作用,无明显的毒副作用,且对于防止2型糖尿病的并发症如脂类代谢异常具有良好作用。

[Objective]To explore the hypoglycemic effects, curative effects and side effects of combined berberine and glipizide on patients with type 2 diabetes. [Methods]One hundred fifty two patients with type 2 diabetes were classified into three groups at random：glipizide （group A）, berberine （group B） and berberine combined with glipizide （group C）. Different drugs were administrated to patients in various group, respectively. Then the concentration of fasting plasma glucose （FPG）, insulin, C peptide, triglyceride （TG）, total cholesterol （TCH）, high density lipoprotein cholesterol （HDL-C）, low density lipoprotein cholesterol （LDL- C）, 2 hours post prandial blood glucose （PBG） and percentage of glycosylated hemoglobin （HbA1C） were monitored to evaluate the curative effects of various treatment. [Results]The FPG and PBG were decreased efficaciously under three processes,and the effective rate of group C was the highest （P d0.05） when compared with group A and B. Glipizide had no effects on metabolism of blood lipids but had some effects on improvement of insulin resistance; administration of berberine or berberine combined glipizide on these patients could not only improve insulin resistance and recover the function of pancreatic island effectually, but also improve the metabolism of blood lipids, no obvious side effects were observed in this research. [Conclusion]Administration of glipizide combined with berberine has satisfactory synergistic effect on patients with type 2 diabetes, and they can effectively decrease the level of blood lipids, improve the status of insulin resistance and recover the function of pancreatic island, and no obvious side effects were observed.