不同药物配伍在早孕无痛人流术中的临床效果分析

The Clinical Study of the Different Compatibility of Drugs During Painless Artificial Abortion of Early Pregnancy

目的探讨人工流产镇痛方式的最佳药物配伍组合。方法选择ASAⅠ级人工流产者800例,随机分为四组,每组200例。A组:芬太尼50ug、安定10mg;B组:芬太尼50ug、阿托品0.2mg和丙泊酚2.0～2.5mg/kg;C组:芬太尼20ug、阿托品0.2mg和丙泊酚2.5mg/kg;D组:芬太尼20ug、阿托品0.2mg、安定5mg和丙泊酚2.0～2.5mg/kg。评价镇痛效果、循环、呼吸系统变化及副作用。结果B组镇痛效果满意,术后恢复良好,于其它三组比较,有显著性差异(P<0.05),而循环、呼吸系统变化及副作用,四组间比较无显著性差异(P>0.05)。结论芬太尼50ug、阿托品0.2mg、丙泊酚2.0～2.5mg/kg联合静脉麻醉镇痛效果满意、苏醒快、副作用小,是一种较理想的人工流产镇痛方法。

Objective To study the best clinical effect on termination of early pregnancy by giving the different compatibility of drugs during painless artificial abortion. Methods 800 women with ASA class Ⅰ who asked for painless artificial abortion were divided randomly into four groups： A group （200 cases） were intravenous injected with fentanyl 50μg, and diazepam 10mg before operation, B group （200 cases） with fentanyl 50μg, atropine 0.2mg and propofol 2.0-2.5mg/kg before operation, C group （200 cases） with fentanyl 20μg, atropine 0.2mg and propofol , D group（200 cases） with fentanyl 20μg, diazepam 5mg, atropine 0.2mg and propofol 2.0-2.5mg/kg before operation. The analgesic effect, respiratory and circulatory system complications were observed in four groups. Results There was the best analgesic effect in B group, the difference between B and the others was significant（p〈0.05）, but respiratory and circulatory system complications had no significant difference among four groups（p〉0.05）. Conclusions The analgesic effect by fentanyl 50μg, atropine 0.2mg and propofol 2.0-2.5mg/kg is satisfied for artificial abortion. It＇s one of better ways for the artificial abortion analgesic.