3，4，5－三甲氧基苯甲醛合成工艺改进

REVISED METHOD FOR PREPARATION OF 3,4,5 TRIMETHOXYBENZALDEHYDE

羟基苯甲醛在氧化剂存在下溴化生成３，５－二溴－４－羟基苯甲醛，后者用氯化亚铜作催化剂，在ＤＭＦ溶剂中与甲醇钠反应，生成丁香醛。丁香醛在ｐＨ９～１０之间用硫酸二甲酯甲基化得到医药中间体３，４，５－三甲氧基苯甲醛。对各步反应工艺条件进行了探讨。整个工艺路线简便，总收率达７０％。

Hydroxybenzaldehyde was brominated in the presence of sodium chlorate to 3,5 dibromo 4 hydroxybenzaldehyde, which reacted with sodium methoxide in the presence of cuprous chloride to give syringaldehyde. THe latter was methylated to give 3,4,5 trimethoxybenzaldehyde(TMB). The reaction conditions were studied.