钠离子微电流探测仪在胆道肿瘤诊断中的应用

Preliminary application of electric performance detector in cholangiocarcinoma diagnosis

目的探讨钠离子微电流探测仪在胆道肿瘤诊断中的应用价值。方法选择该院2004年4～7月11例胆道肿瘤病人作为观察对象,其中肝门部胆管癌9例,胆总管下端癌2例,采用钠离子微电流探测仪于手术中6例,肿块标本离体后检测5例。检测部位包括正常胆道组织、瘤组织表面和切面、周围淋巴结。比较肿瘤组织和正常组织钠离子微电流的变化。11例病人胆道肿瘤组织均行石蜡切片病理检查,明确其病变性质。结果11例胆管癌组织和正常胆道组织钠离子微电流有明显的差异,肿瘤组织钠离子微电流均超过30微安培(μA),最高者达到60～70μA,正常胆管组织多在20μA左右,没有1例超过30μA。肝动脉旁有癌细胞转移的肿大淋巴结钠离子微电流均超过30μA。结论利用细胞内阳离子浓度查产生的微电流来诊断肿块的良恶性,快速、简捷、准确,具有潜在的巨大应用前景。

[Objective] To invest the possibility of diagnosis using electric performance detector. [Methods] 11 consecutive cholangiocarcinoma patients were included in this study from April to July in 2004 in our hospital. Six cases were measured during operation and five of them were done on the tumor tissues removed from patients. In each case we checked healthy tissue near the tumor, surface and section of tumor, and lymph nodes surrounding tumor to compare the level of electric performance. All of the tumor tissues was sampled and send to pathology for histopathologically confirmation. [Results] Significant differences of electric performance level were found between the malignant and the healthy tissue. The microamper measured by the device was higher than 30 p.A in all the ma- lignant tissue and some of them reached 60 -70μA. In healthy tissues the microamper was lower than 30 μA. [Conclusion] Using the alkali ion electric performance detector to evaluate the malignant characteristics is a sensitive and efficient diagnosis method.