摘要
异丙肾上腺素(Iso)0.02mg·kg-1每日2次,连续sc5wk可引起大鼠左心室肥厚(LVH),降低心肌顺应性;并使心肌僵硬度常数增加92%,冠脉流量降低14%.与对照组相比,Iso还使心肌线粒体,主动脉和尾动脉壁Ca2+含量分别增加了95%,73%和69%.大鼠于Isosc1wk后分别给予间硝苯地平和硝苯地平10mg·kg-1ig每日2次4wk,均显著减轻Iso引起的LVH,改善冠脉血液供应,降低心肌僵硬度,提高心肌顺应性,并减少心肌细胞线粒体,主动脉和尾动脉壁的Ca2+含量.
After treatment with m nifedipine ( m Nif) or nifedipine (Nif) 10 mg·kg -1 ig twice a day for four weeks, the increases in the ratio of heart wet weight to body weight which was induced by a continued adminidstration of isoprenaline (Iso) 0.02 mg·kg -1 sc twice a day for five weeks were significantly attenuated. The coronary flow was higher in m Nif (12.2±1.0 mL·min -1 ) and Nif groups (12.2±0.9 mL·min -1 ) than that in Iso group (10.3±0.4 mL·min -1 , P <0.01). The myocardial compliances were improved and the stiffness coefficients were decreased by the two drugs. Compared to Iso group, the calcium contents of myocardial mitochondria, aorta and tail artery were reduced remarkably in the m Nif treated group (decreased by 42%, 41% and 40% respectively) and Nif treated group (decreased by 38%, 35% and 37% respectively). Thus this study showed that m Nif and Nif regressed cardiac mass induced by Iso in rats through the mechanisms that may be associated with hemodynamic changes especially diastolic function of heart and inhibiting transmembrane calcium influx.
出处
《中国药理学与毒理学杂志》
CSCD
北大核心
1996年第3期181-184,共4页
Chinese Journal of Pharmacology and Toxicology