胃管状腺癌组织中Fos和Jun蛋白表达及临床意义

Expressions and clinical significance of Fos and Jun proteins in gastric adenocarcinoma

目的:检测Fos和Jun在胃癌组织中的表达,探讨其与胃癌的发生、发展及生物学行为的关系。方法:应用免疫组织化学SABC法检测54例胃癌及癌旁组织中Fos和Jun基因蛋白的表达。数据采用SPSS统计软件包及x2检验分析。结果: c-Fos和c-Jun在胃癌及癌旁组织中的阳性表达率分别为68．5％、27．8％和63．0％、24．1％;c-Fos和c-Jun的表达在胃癌不同组织学分级间差异有统计学意义(x2分别为8．101和6．742;P分别为0．018和0．032),在淋巴结转移和TNM分期间差异无统计学意义(x2分别为1．534、1．342和0．055、0．499;P分别为0．219、0．266和0．832、0．492);胃癌及癌旁组织中c-Fos与c-Jun之间的表达呈正相关。结论:c-Fos和c-Jun基因蛋白表达变化发生在肿瘤细胞形态变化之前,可作为胃癌早期诊断的分子病理学指标。

OBJECTIVE：To detect the expressions of Fos and Jun in gastric carcinoma and study their correlation with the development and biological behaviour of the tumor. METHODS： The expressions of gene proteins of Fos and Jun in fifty-four gastric carcinoma and adjacent tissues of gastric carcinoma were detected by the immunohistoehemieal method of SABC. Statistical analysis were calculated by SPSS system and Chi-Square test. RESULTS： Positive cytoplasmic immunoreaetivities were seen in a proportion of 68.5% and 27.8% for c-Fos, 63.0% and 24. 1% for c-Jun in the samples of gastric cancer and adjacent tissues of gastric carcinoma. The significant difference was present in the expressions of c-Fos, c-Jun among different histologic types（x^2=8. 101, 6. 742; P= 0.018, 0.032）, but wasn＇t present among different status of regional lymph nodes and TNM stages （x^2= 1.534, 1.342, 0.055, 0.499; P=0.219, 0.266, 0.832, 0.492）. There was a positive correlation between the expressions of c-Fos and c-Jun in gastric carcinoma and nearby carcinoma tissues. CONCLUSIONS： The expressions of c-Fos and c-Jun maybe provide proofs for gastric carcinoma grouping, and it can be used as the molecular pathological symbols for early diagnosis.