三维适形放射治疗腹腔淋巴结转移癌43例疗效分析

Three-dimensional conformal radiotherapy for 43 patients with metastasis of retroperitoneal lymph node

目的:分析三维适形放射治疗(3-DCRT)腹腔淋巴结转移癌的疗效。方法:从1999年5月～2002年8月采用3-DCRT技术治疗腹腔淋巴结转移癌患者43例,剂量-时间-分割方式:2．5～3．0 Gy／次,5次／周,12～16次,总剂量35～40 Gy。结果:43例患者均顺利完成治疗,完全缓解(CR)14例,部分缓解(PR)22例,总有效率(cR+PR)83．7％。近期疗效与病灶体积及病理类型有关,病灶体积越小效果越好(2=3．007,P=0．003),未分化癌疗效优于鳞癌和腺癌(z=3．52,P=0．001), 1、2和3年生存率分别为54％、21％和7．0％。结论:3-DCRT治疗腹腔淋巴结转移癌有较好的疗效,放疗反应轻。

OBJECTIVE： To evaluate the outcome of metastatic retroperitoneal lymph nodes treated with three-dimensional contormal radiotheraphy（3-DCRT）. METHODS：From May 1999 to August 2002, 43 patients of metastatic retroperitoneal lymph nodes were treated with 3-DCRT. The prescription dose-time-fraction was 2. 5- 3. 0 Gy per fractions, 5 times per week, the total was 12 to 16 fractions, and the total dose was 35- 40 Gy. RESULTS： All cases completed the radiation, 14 patients achieved CR, 22 PR, with a total response （CR＋PR） 83. 7%. The early response was related to the target volume and pathological classification. The smaller target volume,the better the response. The ansplastic carcinoma cases had better result than the squamous carcinomas and adenocarcinomas. The 1, 2 and 3 year surrival rates were 54%, 21% and 7. 0%. CONCLUSIONS： The three-dimensional conformal radiotheraphy is an effective and feasible approach in the treatment of metastatic retroperitoneal lymph nodes.