造血发育和内皮细胞的关系

Relationship Between Hematopoietic Development and Endothelial Cells (Hemangioblast or Hemogenic Endothelium) ——Review

研究造血和血管内皮在胚胎发育中的关系,包含对造血细胞和内皮细胞的发育起源以及相关分子调控的探讨。以已有的研究结果为基础,对造血细胞和血管内皮细胞发育关系提出了成血血管细胞(hemangioblast)和生血内皮(hemogenic endothelium)的两种模式。在卵黄囊和P-Sp/AGM区,造血和内皮细胞的发育关系分别表现出不同的特点:二者在卵黄囊共同来源于成血血管细胞;在AGM区则更多表现为生血内皮的模式。造血和血管内皮相关分子的表达和调控作用的研究,不仅体现了造血和内皮在发育中的密切关系,同时也加深了对造血发育调控的认识。本文就原始造血和永久造血的发育、造血和血管内皮发育相关的两种模式及造血和内皮发育相关分子问题进行了综述。

Developmental programs of blood and endothelium are closely correlated and remarkably conserved among species. To categorize the ontogeny relationship between hematopoietic and endothelial lineages, two putative models are presented here. In the yolk sac, hematopoietic and endothelial cells are more likely derived from a common precursor- the hemangioblast. By comparison, the hemogenic endothelium is proposed to characterize the generation of hematopoietlc stem cells from mature endothelium in the P-Sp/AGM region. Furthermore, couples of molecules, including Scl, Flk-1 and Runx-1, are involved in formation and subsequent differentiation of the hemangioblast or hemogenic endothelium during embryonic hematopoiesis. In this article, the development of primitive and definitive hematopoiesis, two models associated with development of hematopoietic and vascular endothelial cells as well as molecules associated with development of hematopoietic and endotheliate cells were summaried.