摘要
人线粒体基因组包括1 500多个基因,分属于线粒体DNA(m tDNA)和核基因组DNA(nDNA)两个部分。除m tDNA自身编码的37个基因外,其余与线粒体结构和功能相关的基因均由nDNA编码。线粒体产生的大量活性氧类(ROS)可致m tDNA突变,继而诱发衰老及许多与衰老相关的疾病,包括神经退行性疾病、心肌病、糖尿病和恶性肿瘤等。
The human mitochondrial genome consists of approximate 1500 genes,among which 37 are encoded by the mitochondrial DNA （mtDNA） and the remainder encoded in the nuclear DNA （nDNA）. The mitochondria produces large amount of the cellular reactive oxygen species （ROS）. ROS induces the mutations of mtDNA and mtDNA, which are associated with a wide range of age-related diseases including neurodegenerative diseases,cardiomyopathy,diabetes and various cancers.
出处
《浙江大学学报（医学版）》
CAS
CSCD
2007年第1期93-97,共5页
Journal of Zhejiang University(Medical Sciences)
基金
浙江大学医学院科研启动基金(41900-542937)
关键词
衰老
DNA
线粒体
突变
活性氧/代谢
神经变性疾病
Aging
DNA, mitochondrial
Mutation
Reactive oxygen species/metab
Neurodegenerative diseases
