乳腺癌组织中VEGF-C的表达及其与临床病理指标的关系

Expression of VEGF-C in Breast Cancer Related with Clinicopathological Factors

目的:探讨血管内皮生长因子-C(vascularendothelialgrowthfactorC,VEGF-C)在乳腺癌组织的表达情况及与临床病理指标的关系。方法:应用免疫组织化学方法检测69例乳腺癌和10例乳腺纤维腺瘤组织的VEGF-C表达情况,并分析其表达与临床病理特征的关系。结果:69例乳腺癌组织中VEGF-C阳性表达72.46%(50/69),10例乳腺纤维腺瘤表达为30%,两者差异有统计学意义(Hc=10.173,P<0.01)。VEGF-C在乳腺癌中的表达与其组织学分级有关(χ2=12.026,P<0.01),组织学分化Ⅲ级的VEGF-C阳性表达率为92.86%,高于组织学分化Ⅰ级(37.5%,P<0.01)、Ⅱ级(63.64%,P<0.05),Ⅰ级与Ⅱ级比较差异无统计学意义(P>0.05);有腋淋巴结癌转移组与无转移组的VEGF-C阳性表达率分别为87.10%和60.53%,差异有统计学意义(P<0.05);而与月经状态、肿瘤大小、病理类型、TNM分期、ER/PR状态和预后无关(均P>0.05)。结论:乳腺癌组织中VEGF-C的表达明显增加,其表达水平显著高于乳腺纤维腺瘤,并且与肿瘤组织学分级、区域淋巴结转移有关。

Objective： To investigate the expression of VEGF-C （vascular endothelial growth factor C） in human breast cancer and evaluate their clinical significance. Methods： Immunohistochemical staining was performed to examine the expression of VEGF-C in sixty-nine cases of breast cancer and ten breast fibroadenoma tissues and analyzed relationship between the expression of VEGF-C and the clinical pathological features. Results： Positive expression of VEGF-C in all sixtynine cases of breast cancer （72.46%, 50/69） was higher than those in ten fibroadenoma tissues （30%）, the difference had statistical significance （Hc=10.173, P 〈 0.01）. There was a significant relationship between the expression of VEGF-C and the histological grade in breast cancer （χ^2 = 12.026, P 〈 0.01） and the positive expression of VEGF-C in grading Ⅲ （92.86%） was higher than those in grading Ⅱ （63.64%, P 〈 0.05）and grading Ⅰ （37.5%, P 〈 0.01）. No significance was found between grading Ⅱ and grading Ⅰ （P 〉 0.05）. The positive expression of VEGF-C in those with metastatic axillary lymph node （87.10%） was higher than those without metastatic （60.53%）, the difference had statistical significance（P 〈 0.05） and no relationships were related with the menstruation status, tumor size, histological type, TNM stage, EP/PR and prognosis （P 〉 0.05）. Conclusion： The expression of VEGF-C increase in breast cancer and is significantly higher than those in the breast fibroadenoma ,moreover, it is associated with grading and metastasis in axillary lymph node.