干细胞与组织工程在肠道的研究进展

INTESTINAL STEM CELLS AND TISSUE ENGINEERING TECHNIQUE USED IN TREATING INTESTINAL DISEASES

目的了解干细胞和组织工程在肠道的研究进展。方法查阅近年相关文献,总结干细胞和组织工程在肠道的研究现状。结果干细胞和组织工程在肠的研究近年来是个十分令人关注的领域,亦取得一定的进展。特别是在肠道上皮干细胞的特性、增殖、分化、小肠黏膜下层作为体内组织工程支架等方面的研究有一定的突破。但困扰研究的关键问题是小肠上皮干细胞的标记物仍未得到解决,组织工程肠的研究亦刚刚起步。结论干细胞和组织工程在肠道的研究有十分广阔的应用前景,有望在肠道炎性疾病、肿瘤发生机制、组织工程肠的研究方面取得较好的研究成果。

Objective To review the development of researches on the stem cells and the tissue engineering technique used in the intestines. Methods We comprehensively reviewed the literature related to the stem cells and the tissue engineering technique used in the intestines, and summarized the conclusions made by the researches concerned. Results The researches on the stem cells and the tissue engineering technique used in the intestines were attractive topics in the recent years and obtained some developments, especially in the field dealing with the characteristics, proliferation and differentiation of the intestinal stem cells as well as the tissue engineering framework of the small intestinal submucosa in vivo. However, the markers for the differentiation of the intestinal stem cells were still a critical problem, which had not been solved yet, and besides, the researches on the intestinal tissue engineering were still in the initial stage. Conclusion There is a broad prospective application of the intestinal stem cells and the tissue engineering technique to the intestinal problem solution. Substantial achievements can be obtained in the treatment of the inflammatory bowel disease, in an exploration on the oncogenesis mechanism, and in the clinical application of the intestinal tissue engineering.