小白鼠心阻抗微分图正常值分析

DETERMINATION AND ANALYSIS OF HEART FUNCTION BY IMPEDANCE CARDIOGRAPHY IN MICE

本文采用阻抗法无创性心功能血流动力学计算机实时监测系统，对３０只小鼠的心功能进行了测定。其心阻抗微分图的Ａ、Ｃ、Ｏ波明显，且均与心电图（ＥＣＧ）的Ｐ波、ＱＲＳ波、Ｔ波在时间上相对应。获得了麻醉小鼠的心功能参数，其中心率（ＨＲ）为５５２．４７±８０．７３ｂｅａｔ／ｍｉｎ，射血前期（ＰＥＰ）为２５．８６±４．８０ｍｓ，左室射血期（ＬＶＥＴ）为５８．８３±９．１３ｍｓ，心输出量（ＣＯ）为２．５０±０．８８ｍｌ／ｍｉｎ，心脏指数（ＨＩ）为４６６．７６±１８６．６１ｏｈｍ／ｓ２。雌雄间差异不明显。

The heart function were determined by impedance caridiography with non invasive heart function and hemodynamic computer monitoring system in 30 mice under intraperitoneal sodium pentobarbital anesthesia.The C,A,and C waves which appeared clearly in impedance cardiography paralleled and responded the P,QRS and T waves in ECG.The results showed that the HR was 552 5±80 7 beat/min,PEP 25 86±4 80ms,LVET 58 83±9 13ms,CO 2 50±0 88ml/min,HI 464 8±186 6 ohm/s 2。The difference was not found between male and female mice,but found among mice,rats,rabbits and other species.