己酮可可碱对老年男性急性呼吸道感染病人血浆凝血因子Ⅰ的影响

Effects of pentoxifylline on plasma coagulation factor Ⅰ in old male patients with acute respiratory tract infection

目的：探讨己酮可可碱对老年男性急性呼吸道感染病人血浆凝血因子Ⅰ的影响及其意义。方法：58例老年男性急性呼吸道感染病人随机分为2组,对照组28例予头孢呋新2．0 g加入氯化钠注射液100 mL静脉滴注,每日2次,治疗组30例在对照组治疗的基础上予己酮可可碱0．4 g加入氯化钠注射液250 mL静脉滴注,每日1次,疗程均为14 d。治疗前后检查呼吸道感染相关症状,血常规,痰培养,胸片,肝、肾功能,血浆凝血因子Ⅰ浓度。结果：2组治疗后对照组显效率36%,总有效率92%,治疗组显效率63%,总有效率97%,2组显效差异有显著意义(P＜0．05)。2组的血浆凝血因子Ⅰ浓度较治疗前显著降低(P＜0．01)。结论：己酮可可碱促进老年急性呼吸道感染的恢复,对高凝状态有较好的疗效,有利于预防心脑血管事件的发生。

AIM： To evaluate the effects and significance of pentoxifylline （PTX） on plasma coagulation factorⅠ in old male patients with acute respiratory infection. METHODS： Fifty-eight male patients with acute respiratory tract infection were randomized into two groups. The control group （28 patients） was treated with cefuroxime （20 g, bid, iv） for 14 d, and the treatment group （30 patients） was treated with PTX （0.4 g, bid, iv） and cefuroxime （2.0 g, bid, iv） for 14 d. Infectious symptoms and routine analysis of blood were recorded, the content of plasma coagulation factorⅠ and the function of liver and kidney were measured before and after treatment. RESULTS： The apparent effective rate was 36 % in the control group and 63 % in the treatment group. The total effective rate was 92 % in the control group and 97 % in the treatment group. There was significant difference between the two groups （P 〈 0.05） . Compared with control group, the levels of plasma coagulation factorⅠ of the treatment group was decreased significantly （P 〈 0.01 ） . CONCLUSION ： Pentoxifylline can promote the recovery of acute respiratory tract infection in old male patients, improve the hemorheological condition and prevent the occurrence of cardio-cerebravascunlar.