摘要
目的观察茶氨酸对脑缺血后IL-8、NSE和脑超微结构的影响。方法将30只健康家兔随机分为假手术组、脑缺血组和茶氨酸组。假手术组只手术不结扎动脉不使用药物、脑缺血组结扎动脉不使用药物、茶氨酸组结扎动脉并在再灌注时应用茶氨酸。全部动物于缺血前（I）、再灌注时（R0）、再灌注1h（R1）、4h（t12）、12h（R3）、24h（1／4）静脉采血进行白介素-8（IL-8）和神经特异性烯醇化酶（NSE）测定，全部采血完毕后每组取一只动物开颅取3～5块约1mm^3大脑皮层组织进行超微结构观察。结果茶氨酸组脑超微结构改变以及血清IL-8和NSE含量变化均明显轻于脑缺血组。结论提示茶氨酸具有神经保护作用，且无毒副作用，有进一步研究和开发价值。
Objective To observe the changes of IL-8, NSE and histopathology of the induced brain damnification by ischemia. Methods 30 healthy rabbits were divided into three groups randomly： （1）sham-operated group（2）ischemia group administered ischemia and repeffusion and （3）theanine-treated group administered theanine just before reperfusion. Blood was gathered from jugular before ischemia, before reperfusion and at I h, 4h, 12h and 24h after reperfusion in order to measure IL-8 and NSE levels. Histopathological changes were evaluated afterwards. Results In the theanine-treated group , all of the above changes were less severe than those in the control group. Conclusion Theanine has fine neuro-protective effect and has no side effect. Further studies and exploitation are warranted.
出处
《中国医师杂志》
CAS
2007年第1期4-6,共3页
Journal of Chinese Physician
基金
基金项目：山西省高校科技研究开发项资助项目（20041324）
