脑膜炎奈瑟氏菌对常用抗菌药物敏感性监测

Surveillance on Antibiotic Sensitivity of Neisseria meningitidis

本文就１９６６～１９９３年２１个省市分离的２１８株Ａ、Ｂ和Ｃ群脑膜炎奈瑟氏菌（Ｎｍ）对７种常用抗菌药物的敏感性进行了监测。在１０８株Ａ群Ｎｍ中２０株（１８．５％）对ＳＭＺ耐药，其中１７．３％的病人菌株，２１．２％的带菌者菌株耐药；３１株（２８．７％）对ＡＳＰ耐药。在１０１株Ｂ群Ｎｍ中４０株（３９．６％对ＳＭＺ耐药。其中４３．３％的病人菌株和３４．１％的带菌者菌株耐药，１７株（１６．８％）对ＡＳＰ，１０株（９．９％）对ＣＦ耐药。在９株Ｃ群Ｎｍ中５株对ＳＭＺ，２株对ＡＳＰ耐药。未发现Ｎｍ对Ｃｈｌ耐药。实验结果提示我们今后在流脑治疗和化学预防上应加强Ｎｍ对抗菌药物敏感性的监测，这有助于提高这些药物对流脑防治的效果。

218 strains of Neisseria meningitidis(Nm)serogroup A,B and C were collected from 21 provinces of China in 1966～1993,their sensitivity to 7 routine antibiotics were determined by using the method of improved Kirby Bauer and agar dilution.On 108 strains of serogroup A Nm tested,20 strains were discovered to be resistant to SNZ,(of which 13 strains were isolated from patients and 7 strains frombacterium carriers),31 strains resisted ASP.In 101 strains of serogroup B Nm,40 straino resisted SNZ r.(of which 26 strains isolated from patients and 14 straino from bacterium carriers);17 strains resisted ASP and 10 strains resisted CF.In 9 strains of serogroup C Nm,5 strains resisted SMZ r;2 strains resisted ASP.We did not discovered the risistant Chl straim of Nm.The results showed that we should strengthen the surveillance on the antibiotic sensitivity of Nm in the control of epidemic meningitis.